Active Projects >>>
Patient Hand Hygiene Intitiative
Lona Mody | Centers for Disease Control & Prevention | 09.30.2016 - 09.29.2017
The overarching goals of this contract are to: 1) using molecular epidemiologic methods to characterize the role of patient hand carriage of multidrug-resistant organisms on environmental contamination and thus establish predictors and consequences of patient hand contamination; 2) conduct a systematic review to document the prevalence of multidrug-resistant organism hand colonization of patients and healthcare personnel, and transmission pathways between the environment and patients; and 3) develop efficient, cost‐effective and sustainable interventions that promote and disseminate patient hand hygiene programs in various settings where healthcare is provided including acute care hospitals, nursing homes, outpatient settings, ambulatory surgery and dialysis centers.
Enhancing Patient Safety by Preventing Device-Associated Harm
Sanjay Saint | VA National Center for Patient Safety | 10.01.2015 - 09.30.2018
The general theme of this Patient Safety Center of Inquiry (PSCI) is preventing healthcare-associated infection. Our goal is to enhance the safety of patients by promoting the safe and appropriate use of urinary catheters and peripherally inserted central catheters (PICCs) to prevent device-associated infections.
Engaging Partners in Infection Prevention and Control in Acute Care Hospitals
Sanjay Saint | HRET-CDC | 10.01.2015 - 09.30.2018
The purpose of this project is to improve the implementation of infection prevention efforts in acute care hospitals across the United States. We will study at least 300 short-stay and long-term acute care hospitals that have a high burden of four key healthcare-associated infections: central line-associated bloodstream infection (CLABSI), catheter-associated urinary tract infection (CAUTI), Clostridium difficile infection (CDI), and Methicillin resistant Staphylococcus aureus (MRSA).
Enhancing Patient Safety through Cognition & Communication: The "M-Safety Lab"
Sanjay Saint | AHRQ | 09.30.2015 - 09.29.2019
Our overarching goal is to implement novel methods to enhance cognition and communication among care providers in order to reduce hospital-acquired complications. Our center-wide aim is to establish a cohesive M-Safety Lab comprised of multidisciplinary, collaborating teams of investigators supported by a robust infrastructure including and Innovation, Development, Evaluation and Administration Core that will help oversee the development and successful completion of both projects from problem analysis to evaluation and will provide methodological, technical, and administrative support. The aim of project 1 is to develop, refine, and test a comprehensive inpatient monitoring system to reduce two common, harmful, and costly patient safey problems: healthcare-associated infections and pressure ulcers. The aim of project 2 is to develop, design, implement and evaluate interventions that combine cognitive and technology-based system-wide innovations to improve diagnostic and therapeutic decision-making around diagnostic error, blood transfusion and antimicrobial use.
HRET Hospital Engagement Network 2.0
Sanjay Saint | HRET-CMS | 9.24.2015 - 09.23.2016
The long-term goal of this project, in collaboration with the Health Research & Educational Trust (HRET), is to help participants in the Hospital Engagement Network identify, implement and evaluate catheter-associated urinary tract infection (CAUTI) prevention strategies that are most effective in reducing overall catheter use and CAUTI rates.
Comprehensive Unit-based Safety Program (CUSP) to reduce Central Line-associated Blood Stream Infections (CLABSI) and Catheter-associated Urinary Tract Infections (CAUTI) in Intensive Care Units (ICU) with persistently elevated infection rates
Sanjay Saint | HRET-AHRQ | 09.14.2015 - 03.03.2017
The purpose of this project is to develop and implement a program to support implementation, adoption, and use of CUSP to reduce CLABSI and CAUTI in ICUs with persistently elevated infection rates throughout the US through regional consortia/collaborative efforts in a phased approach.
Preventing Infections and Antimicrobial Resistance in the Aging Population: Translational Research and Training Program
Lona Mody | NIH-NIA | 08.01.2015 - 03.31.2020
The candidate’s career objectives are to conduct patient-oriented research that improves outcomes from infectious diseases and reduces antimicrobial resistance in a vulnerable older population and to train a multidisciplinary group of students, residents, fellows, nurse investigators and junior faculty who wish to conduct patient-oriented and outcomes research in infection prevention. The majority of her professional life has been dedicated to the conduct of patient-oriented research in infection prevention, establish a steady stream of funding from NIA and other sources and organize numerous career-development programs in aging research nationally.
Intervening in the Emergency Department to Reduce Urinary Catheter Use
M. Todd Greene & Sanjay Saint | NIH | 08.01.2015 - 07.31.2017
The immediate goals of this project are: 1) to develop an understanding of the extent to which urinary catheter use in emergency departments can be reduced following interventions focused on appropriate indications for catheter placement; and 2) to identify organizational, personnel and other contextual factors that either facilitate or impede placing urinary catheters in the emergency department only when appropriately indicated. These immediate goals will contribute to the long-term goal of identifying and implementing effective strategies to reduce inappropriate catheter use in the ED, thereby reducing overall catheter use and preventing catheter-associated urinary tract infection (CAUTI).
Identifying and Reducing Catheter-Related Complications
Sarah Krein & Sanjay Saint | Department of Veterans Affairs HSR&D | 07.01.2014 - 12.31.2018
The purpose of this multi-site study is to identify, better understand, and then develop strategies to address the full range of complications – infectious and non-infectious – associated with the use of urinary catheters and peripherally inserted central venous catheters (PICCs).
National Implementation of Comprehensive Unit-based Safety Program (CUSP) to Reduce Catheter-associated Urinary Tract Infection (CAUTI) in Long Term Care Facilities
Lona Mody & Sanjay Saint | AHA-AHRQ | 09.19.2013 - 09.18.2016
The purpose of this project is to develop and implement a program for the support development, implementation, the adoption, and use of a Comprehensive Unit-based Safety Program (CUSP) to reduce Catheter-associated Urinary Tract Infection (CAUTI) in long term care facilities in all States, the District of Columbia, and Puerto Rico through State-based or regional consortia/collaborative efforts in a phased approach. Our goal is to implement and evaluate a program to reduce CAUTI in approximately 500 nursing homes nationwide.
Recovery After in Hospital Cardiac Arrest Late Outcomes and Utilization (ResCU)
Theodore Iwashyna & Brahmajee Nallamothu | VA ORD | 08.01.2014 - 07.31.2017
The fundamental goal of the ResCU proposal is to understand patterns of long-term outcomes and healthcare utilization across hospitals after IHCA and then to use these insights to develop new strategies for quality improvement both within the VHA and elsewhere. Its 3 Aims will: (1) measure long-term outcomes (including health status) and healthcare utilization in patients after IHCA within the VHA and then determine key patient-level factors that are linked to adverse outcomes; (2) identify hospital-level factors that are associated with long-term outcomes and healthcare utilization; and (3) determine the extent of variation in long-term outcomes across hospitals and VISNs for purposes of feedback and benchmarking.
Hospital Enhancement of Resuscitation Outcomes for In-Hospital Cardiac Arrest (HEROIC)
Brahmajee Nallamothu | UM-NIH | 07.01.2012 - 06.30.2016
In-hospital cardiac arrest (IHCA) is a common event with poor survival. Yet, some hospitals are more successful in preventing and treating IHCA than others. This proposal lays the foundation for future quality efforts in IHCA by identifying specific and practical resuscitation strategies adopted by top-performing hospitals through a sequential mixed-methods study design that uses both quantitative and qualitative approaches. As part of this study, the University of Michigan team will be primarily responsible for arranging and conducting on-site, semi-structured interviews with key stakeholders at a random sample of top and bottom performing hospitals identified through a national registry. Through site tours and observations, we will collect data on each institution’s resources and physical lay-out, review documents and policies related to the prevention and management of IHCA, and identify quality improvement initiatives and innovations.
Improving Peripherally Inserted Central Catheter Use in Hospitalized Patients
Vineet Chopra | AHRQ | 04.01.2014 - 03.31.2018
This is a career development award for Dr. Vineet Chopra. The candidate will pursue a mentored research plan that will promote development of expertise in: 1) hospital epidemiology, vascular biology, and infection prevention; 2) analysis of longitudinal, categorical, and survival data; 3) decision-making, leadership and cost-effectiveness; and 4) implementation science. The career development plan consists of a multidisciplinary team of experienced mentors and advisors who will oversee a range of formal coursework and practical experiences to ensure the candidates’ success. Exceptional resources and a mentoring team with proven success in developing junior physician-scientists make the University of Michigan an ideal environment for this proposal.
The Effect of Health Information Technology on Healthcare Provider Communication
Milisa Manojlovich | AHRQ | 09.30.2014 - 09.29.2018
The purpose of this study is to understand how communication technologies facilitate or hinder communication between nurses and physicians.
Predictors of Hospital-Acquired Urinary Tract-Related Bloodstream Infection in VA
Sanjay Saint | VA Merit Grant | 07.01.2012 - 06.30.2016
The objective of this VA-based clinical study is to delineate both host- and time dependent factors that contribute to urinary tract-related bloodstream infection in hospitalized veterans. This study is unique in that it will ascertain potential causal mechanisms of bloodstream infection taking into account the time course of a hospitalized patient’s stay and the multiple procedures and treatments that occur during this stay.